The only way to regress the damage done to the eyes of a Mangekyo Sharingan users has been to use Hashirama's cells, such as with what happens with Shisui's eyes. Even then, it is unknown if it improves or prevents damage, it just strengthens use. As to nullifying effects, no, the Six Paths Chakra was never said to prevent blindness, you can nullify the effects of an Izanagi on a Sharingan by activating the Rinnegan though, such as with what happened to Madara.

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  • Does six paths chakra nulify the effects of blindness caused by the mangekyo sharingan
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  • The only way to regress the damage done to the eyes of a Mangekyo Sharingan users has been to use Hashirama's cells, such as with what happens with Shisui's eyes. Even then, it is unknown if it improves or prevents damage, it just strengthens use. As to nullifying effects, no, the Six Paths Chakra was never said to prevent blindness, you can nullify the effects of an Izanagi on a Sharingan by activating the Rinnegan though, such as with what happened to Madara.
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abstract
  • The only way to regress the damage done to the eyes of a Mangekyo Sharingan users has been to use Hashirama's cells, such as with what happens with Shisui's eyes. Even then, it is unknown if it improves or prevents damage, it just strengthens use. As to nullifying effects, no, the Six Paths Chakra was never said to prevent blindness, you can nullify the effects of an Izanagi on a Sharingan by activating the Rinnegan though, such as with what happened to Madara.
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