* This is the second time Lois has a midlife crisis, after "Go, Stewie, Go!".
* "Conway Bieber" sings "Only Make Believe".
* Stewie mentions that Sheldon without his shell to a "nude Larry David", comparing him to the co-creator of Seinfeld.
* Lois celebrates her 43rd birthday in the episode.
* Sheldon inadvertently saves Meg's life by swapping her sleeping pills with Alka-Seltzer tablets, foiling her suicide attempt.
* Lois' tattoo on her back says "Serenity."
* Alex Borstein was nominated at the 65th Primetime Emmy Awards for Outstanding Voice-Over Performance for playing Lois Griffin and Tricia Takanawa in this episode. She lost to Lily Tomlin for narrating the HBO documentary An Apology to Elephants. http://www.emmys.com/nominations/2013/Outstanding%20Voice-Over%20Performance