Born in Iowa City, Iowa, Griffith was a four-time college football letter winner for the University of Iowa from 1897 to 1900. Griffith, a fullback, played for some of the greatest teams in Iowa football history. Against Illinois in 1899, Griffith returned a punt 85 yards as Iowa won, 58–0, to cap an undefeated season. After the game, referee R. T. Hoagland of Princeton said, "The dodging run of Griffith down the field for a touchdown was the best piece of individual playing that I ever saw. The men (of the 1899 Hawkeyes) are all stars; they make the best team I ever saw."