* This is the third episode to have the name Joe in the title following "Believe It or Not, Joe's Walking on Air" and "Joe's Revenge".
* In a cutaway gag, Gene Shalit's wife is named JoAnne. In reality, he is a widower and his late wife's name was Nancy.
* This is Mike Desilets first solo writing credit.
* Tom Petty And The Heartbreakers' "Runnin' Down A Dream" plays when Brian experiences a runner's high.
* "Sirius" by The Alan Parsons Project plays during the laser introduction of The Hopeful Squirrel 2.
* A week after this episode aired, Bono revealed the real reason he wore sunglasses was because he was going blind from glaucoma.http://www.news.com.au/entertainment/celebrity-life/u2-frontman-bono-reveals-why-he-always-wears-dark-glasses/story-fn907478-1227094663463