Rüstem Pasha Opuković (; ; 1500 – 10 July 1561) was an Ottoman statesman. He served as the grand vizier of sultan Suleiman the Magnificent. Rüstem Pasha is also known as Damat Rüstem Pasha (the epithet damat meaning "bridegroom" to the Ottoman dynasty) because of his marriage to one of the sultan's daughters.