About: BP-554   Sponge Permalink

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By competitive radioligand binding assay, BP-554 has a Ki = 4.7 nM for binding at the 5-HT1A receptor, with substantial selectivity in vitro (several orders of magnitude) versus a variety of other receptors, including 5-HT1 receptors and 5-HT2 receptors. Serotoninergic transmission selectively mediated through the 5-HT1A receptor has previously shown to be tightly linked to aggression; selective antagonism of 5-HT1A has been shown to reduce aggression. Thus, BP-554 is a potent stimulant of hyperactivity and aggression in humans.

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  • BP-554
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  • By competitive radioligand binding assay, BP-554 has a Ki = 4.7 nM for binding at the 5-HT1A receptor, with substantial selectivity in vitro (several orders of magnitude) versus a variety of other receptors, including 5-HT1 receptors and 5-HT2 receptors. Serotoninergic transmission selectively mediated through the 5-HT1A receptor has previously shown to be tightly linked to aggression; selective antagonism of 5-HT1A has been shown to reduce aggression. Thus, BP-554 is a potent stimulant of hyperactivity and aggression in humans.
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abstract
  • By competitive radioligand binding assay, BP-554 has a Ki = 4.7 nM for binding at the 5-HT1A receptor, with substantial selectivity in vitro (several orders of magnitude) versus a variety of other receptors, including 5-HT1 receptors and 5-HT2 receptors. Serotoninergic transmission selectively mediated through the 5-HT1A receptor has previously shown to be tightly linked to aggression; selective antagonism of 5-HT1A has been shown to reduce aggression. Thus, BP-554 is a potent stimulant of hyperactivity and aggression in humans. It was originally synthesized and characterized by Matsuda et al. in 1989 at Osaka University and Mitsubishi Kasei Co. at Japan.
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