Gem of Efficacious Toxin is a Legendary Gem in Diablo III. It can only be socketed into Amulets and Rings, and drops from Greater Rift Guardians. This gem causes any attacked enemy (regardless of the Proc Coefficient of the attack, skill or spell) to suffer Poison damage over time. This effect is renewed by further attacks, but does not stack. Upgrading increases the total damage done (and the damage per second). Any damaging attack made by the player character or their pets will apply the poison. However, it will only be applied on cast. As a result, DoT effects will not refresh the poisoning.
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