* Peter's sudden reaction at the end of his long speech with Quagmire is a homage to Jackie Gleason.
* The gag of the unfinished drawing of the traffic jam is an homage to the cartoon Duck Amuck.
* The gag involving the grandfather reading the storybook to his bed-ridden grandchild is a reference to The Princess Bride in which a very similar story interruption occurs. The character is intended to be Peter Falk who performed the role in the film.
* When Quagmire asks Meg to come in his house for some Crystal Light, she says "Well, I do believe in me." This is a reference to a 1980's Crystal Light marketing campaign that used the slogan "I believe in Crystal Light, because I believe in me." http://www.youtube.com/watch?v=6DB9GxrcjUQ