About: Sertralin   Sponge Permalink

An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

The efficacy of sertraline for depression is similar to that of older tricyclic antidepressants, but its side effects are much less pronounced. Differences with newer antidepressants are subtler and also mostly confined to side effects. Evidence suggests that sertraline may work better than fluoxetine (Prozac) for some subtypes of depression. Sertraline is highly effective for the treatment of panic disorder, but cognitive behavioral therapy is a better treatment for obsessive-compulsive disorder, whether by itself or in combination with sertraline. Although approved for social phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions. Sertraline also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeuti

AttributesValues
rdfs:label
  • Sertralin
rdfs:comment
  • The efficacy of sertraline for depression is similar to that of older tricyclic antidepressants, but its side effects are much less pronounced. Differences with newer antidepressants are subtler and also mostly confined to side effects. Evidence suggests that sertraline may work better than fluoxetine (Prozac) for some subtypes of depression. Sertraline is highly effective for the treatment of panic disorder, but cognitive behavioral therapy is a better treatment for obsessive-compulsive disorder, whether by itself or in combination with sertraline. Although approved for social phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions. Sertraline also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeuti
dcterms:subject
dbkwik:babyish/pro...iPageUsesTemplate
bioavailability
  • 44.0
verifiedrevid
  • 395211368(xsd:integer)
metabolism
  • Hepatic
excretion
  • Renal
ATC prefix
  • N06
Legal Status
  • Rx-only
N
  • 1(xsd:integer)
Width
  • 200(xsd:integer)
molecular weight
  • 306(xsd:double)
InChIKey
  • VGKDLMBJGBXTGI-SJCJKPOMBV
protein bound
  • 98.5
IUPAC name
  • -4(xsd:integer)
PubChem
  • 68617(xsd:integer)
CAS number
  • 79617(xsd:integer)
H
  • 17(xsd:integer)
InChI
  • 1(xsd:integer)
pregnancy category
  • C
smiles
  • Clc1ccc[C@H]3c2c[C@@H]CC3
ChemSpiderID
  • 61881(xsd:integer)
ATC suffix
  • AB06
cl
  • 2(xsd:integer)
elimination half-life
  • 93600.0
Image
  • Sertraline-A-3D-balls.png
UNII
  • QUC7NX6WMB
DrugBank
  • DB01104
routes of administration
  • Oral
C
  • 17(xsd:integer)
abstract
  • The efficacy of sertraline for depression is similar to that of older tricyclic antidepressants, but its side effects are much less pronounced. Differences with newer antidepressants are subtler and also mostly confined to side effects. Evidence suggests that sertraline may work better than fluoxetine (Prozac) for some subtypes of depression. Sertraline is highly effective for the treatment of panic disorder, but cognitive behavioral therapy is a better treatment for obsessive-compulsive disorder, whether by itself or in combination with sertraline. Although approved for social phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions. Sertraline also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeutic doses or intermittently for its treatment. Sertraline shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, insomnia, and sexual side effects; however, it does not cause weight gain, and its effects on cognition are mild. The unique effect of sertraline on dopaminergic neurotransmission may be related to its favorable action on cognitive functions. In pregnant women taking sertraline, the drug was present in significant concentrations in fetal blood, and was also associated with a higher rate of various birth defects. Similarly to other antidepressants, the use of sertraline for depression may be associated with a higher rate of suicidality. Due to the rarity of this side effect, statistically significant data are difficult to obtain, and suicidality continues to be a subject of controversy.
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