De_novo puzzles are puzzles where only the primary sequence is known. The peptide (chain) is provided as a straight string which players need to analyse and fold. The goal is to get close to a native low energy folded protein. A prediction of the secondary structure is often given in the comments with a probability for each amino acid being a part of a sheet, an helix or a loop. Many strategies are given by players to start this type of puzzles in strategies pages and videos. see others here Gameplay-Videos
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