* Muramasa Blade: Wolverine's only specific vulnerability known to date. Created by having his soul infused into the katana, the efficiency of his mutant healing factor is decreased dramatically if he sustains injury from the Muramasa Blade. Wolverine has been wounded once with the blade and, though the injury was very minor, it did not heal completely for 2 days.
* Carbonadium Digestion: Wolverine's healing factor is also affected, though to a far less degree, if he ingests Carbonadium.
* Adamantium Allergy: Wolverine was once artificially given Adamantium allergy.
* Adamantium Poisoning: Adamantium has proven to secrete poison which stunts Wolverine's healing factor and feral rage by a very small degree. Even though he has it laced throughout his entire body it has not made a significant change in his abilities. However, the poisoning will endanger Wolverine's life if his healing factor fails on him, such as when an inhibitor field cancels out his mutant powers. Following the loss of his healing factor, Beast is forced to synthesize a drug to counteract the adamantium poisoning so Wolverine can survive it without his healing factor.