About: Fibrosporine   Sponge Permalink

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Fibrosporine ("EP 613593") is a specific small-molecule agonist of TGFβRI (ALK5) that is naturally found in imulsion extract and is believed to in part mediate imulsion's mutagenic properties to the adult human. It was originally characterized by Ellis Pharmaceuticals in their studies of imulsion extract and in the Ellis Pharmaceutical internal collection, is referenced as "EP 613593".

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  • Fibrosporine
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  • Fibrosporine ("EP 613593") is a specific small-molecule agonist of TGFβRI (ALK5) that is naturally found in imulsion extract and is believed to in part mediate imulsion's mutagenic properties to the adult human. It was originally characterized by Ellis Pharmaceuticals in their studies of imulsion extract and in the Ellis Pharmaceutical internal collection, is referenced as "EP 613593".
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abstract
  • Fibrosporine ("EP 613593") is a specific small-molecule agonist of TGFβRI (ALK5) that is naturally found in imulsion extract and is believed to in part mediate imulsion's mutagenic properties to the adult human. It was originally characterized by Ellis Pharmaceuticals in their studies of imulsion extract and in the Ellis Pharmaceutical internal collection, is referenced as "EP 613593". Canonical TGFβ signaling through TGFβRI has been broadly implicated in a diverse number of biological activities, such as fibrosis, cancer, the epithelial-to-mesenchymal transition, and immunological surveillance. Fibrosporine induces global collagen deposition and excessive fibrosity in the adult human, in accordance with the role of TGFβ signaling in extracellular matrix generation. Fibrosporine serves as a mimetic of the TGFβ-1, TGFβ-2, and TGFβ-3 isoforms of ligands through artificial constitutive stimulation of TGFβRI.
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