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| - McDougal appears in the first episode of the series, having killed several soldiers with water alchemy and creating a wall of ice before being confronted by the Elric Brothers. He is defeated by the Elrics and arrested but escapes using steam from a puddle as a diversion. Hoping to enlist other alchemists in his plan, he unsuccessfully tries to convince Solf J. Kimblee to join and retreats back into Central.
- Isaac McDougal, also known as the Freezing Alchemist (氷結の錬金術師, Hyōketsu no Renkinjutsushi), is an original character exclusive to the 2009 series, Fullmetal Alchemist: Brotherhood. Specializing in liquid-based alchemy, he appears in the first episode as a former State Alchemist in the military who is currently trying to destroy Central. After killing a few soldiers with his water alchemy, he activates a transmutation circle to create a large amount of ice. He is then confronted by the Elric brothers Edward and Alphonse, and (after confusing Al for Ed and accidentally making fun of Ed's height) is defeated and handcuffed. He quickly escapes after creating steam from a puddle as a diversion.
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| abstract
| - McDougal appears in the first episode of the series, having killed several soldiers with water alchemy and creating a wall of ice before being confronted by the Elric Brothers. He is defeated by the Elrics and arrested but escapes using steam from a puddle as a diversion. Hoping to enlist other alchemists in his plan, he unsuccessfully tries to convince Solf J. Kimblee to join and retreats back into Central. When confronted by Roy Mustang, McDougal douses the Flame Alchemist in water to halt his fire alchemy. He returns to the transmutation circle he started with and activates it, setting off other transmutation circles around the city. This results in a massive ice wall leading him directly to Central Command. The Elrics battle him again and manage to get the upper hand, wounding McDougal. At a last resort, the alchemist uses his own blood to create a spear to divert them while questioning if they know what truly is happening at Central Command. Escaping them, he retreats down an alley and is confronted by Fuhrer King Bradley. He attempts to kill the Fuhrer and fails when the homunculus draws out his sword and slashes the Freezing Alchemist down. With this in mind, it is hinted that he was aware of Father's plot of the Nationwide Transmutation Circle. He did not, however, seem to know about the Fuhrer's true nature, seeing his final attack resulting in his own death.
- Isaac McDougal, also known as the Freezing Alchemist (氷結の錬金術師, Hyōketsu no Renkinjutsushi), is an original character exclusive to the 2009 series, Fullmetal Alchemist: Brotherhood. Specializing in liquid-based alchemy, he appears in the first episode as a former State Alchemist in the military who is currently trying to destroy Central. After killing a few soldiers with his water alchemy, he activates a transmutation circle to create a large amount of ice. He is then confronted by the Elric brothers Edward and Alphonse, and (after confusing Al for Ed and accidentally making fun of Ed's height) is defeated and handcuffed. He quickly escapes after creating steam from a puddle as a diversion. He later goes to prison to try to enlist Solf J. Kimblee in his plan to destroy Central, but is unsuccessful. Returning to the city, he encounters Colonel Roy Mustang, and quickly escapes from him after dousing him with water. He makes his way back to the alley he originally started at and activates all the transmutation circles around the city that he created, creating a giant wall of ice traveling towards Central. The Elric brothers and Major Alex Louis Armstrong all try to stop him, but are unsuccessful. However, once the Elrics get the upper hand in close combat, he is knocked off and is seriously injured. In desperation, Isaac uses his blood as a weapon to distract the Elrics so he can get away, but not before defiantly yelling out that he was trying to save the country and demanding whether any of them knew who they served or what shape the country was in (meaning that he might have discovered of the Nationwide Transmutation Circle and the Homunculi). After turning down an alley, he confronts Führer King Bradley who, with a slice from his sword, kills Isaac. He is also mentioned in Episode 2 during a report by Colonel Mustang, and is seen again in Episode 30 during his time as a state alchemist in Ishval. In Episode 35, after finally discovering the country-wide circle, Ed remembers about him and understands that he was aware of the military's secret sinister plot. In Episode 50, while mocking the incompetence of Central Headquarters' forces fighting against Mustang's coup d'etat, Major General Olivier Mira Armstrong mentions that she once heard that in the past, one rebel was enough to immobilize the entire Central Headquarters, presumably referring to Issac McDougal.
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