Born in the United States, Yoko learned to speak Japanese through her mother. At some point, Yoko joined Umbrella as an employee of Dr. William Birkin, working in his Laboratory eight miles underneath Raccoon City. In 1996, Yoko took part in an experiment, which was donating her cells as a base to develop t-Virus, without her knowing it, after a "little incident", she found out the truth. Greg Mueller operated on her to alter her memory, make her forget about the incident possibly to cover up the existence of the lab.
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