Ossipee's keel was laid down in June 1861 by the Portsmouth Navy Yard, Kittery, Maine; launched 16 November 1861; sponsored by Mrs. McFarland, wife of the editor of the Concord Statesman; and commissioned 6 November 1862 Lieutenant Commander Robert Boyd in command. Ossipee was one of four sister ships which included USS Adirondack, USS Housatonic and USS Juniata.