USS Mispillion (AO-105) was an Ashtabula-class oiler that served in the United States Navy from 1945 to 1974. She was then transferred to the Military Sealift Command to continue in non-commissioned service as United States Naval Ship USNS Mispillion (T-AO-105), in which capacity she served until 1994. Thus far, Mispillion has been the only U.S. Navy ship to bear the name.