Enos attended Edsel Ford High School in Dearborn, Michigan. He played quarterback and earned all-state honors while passing for 46 touchdowns and compiling 5,743 yards of total offense. Enos played four years at Michigan State University (1987–1990), including two as starting quarterback (1989–1990). Under Enos and then coach George Perles Michigan State won the 1989 Aloha Bowl and 1990 John Hancock Bowl and took a share of the 1990 Big Ten championship. As of 2010 Enos has the third-best all-time pass completion percentage in Spartan history (.621) and eighth-best total yards (4,301). In 1991 Enos graduated from Michigan State with a degree in business administration.