Agent Obersmith was an elite A6 agent working for Jason Wynn. He, Jessica Priest, and Agent Zacks were sent on a mission in Brazil to retrieve a biogenetic weapon, Heat-16.
While traveling through the jungles on a river boat, they were betrayed by their guide, Juuko. While Jessica used her skills to escape, Zacks and Obersmith were taken to the mad scientists Liz Arno and Kevin Bergregor for medical experimentation. They were re-animated by a substance called Nugen 2.07 and turned into feral monsters that could regenerate wounds in seconds. However, this came at a cost of a need for flesh.
Obersmith and Zacks tracked Jessica Priest and the Heat-16 across the Rain Forest and returned the weapon to the scientists. They were tracked in return by Jessica and ultimately murdered.