| Synopsis
| - Web-slinging through the city, Spider-Man decides that he needs to get away from New York and sort out the state of his life. When he happens to see a news reports about the Man-Thing's activities in Florida, Spider-Man decides to try and convince J. Jonah Jameson to send Peter Parker out to Florida to try and get pictures of the Man-Thing. Peter manages to convince Jameson to send Peter out to get photos. Peter then calls his old friend Curt Connors and gets him to agree to help him out since he lives near Florida. He then calls Mary Jane, who is excited that Peter's called her, but disappointed when he tells her he's leaving town for a few days, but she quickly hides this disappointment when her Aunt Anna enters the room.
Meanwhile, in Florida, Curt Connors accidentally knocks down a chemical mixture, the gas from the smashed beaker causes Connors to once more turn into the Lizard. The monster then attacks Connor's wife before returning to the swamps determined to make lizards the dominant life form on the planet, believing that only the Man-Thing poses a threat to his plans.
While back in New York, Peter pays a visit to Gwen Stacy and apologizes for his behavior following her sudden "resurrection" before leaving for Florida. In Florida, Edmond Arnstead, a down and out bio-chemist who has become bankrupt due to the recent recession has come to the swamps in order to commit suicide. However, he is saved by the Man-Thing, the bog-beast being attracted to his emotions and the arrival of a hung alligator. Realizing that he's discovered the location of the Man-Thing, he realizes the money making potential and leaves the scene in his car.
Elsewhere, Spider-Man has arrived in Florida, and before he can arrive at the Connors home, he's attacked by the Lizard. But with an assist by Martha Connors, Spider-Man is able to gain the upper hand against the creature and bind him in webbing. With the Lizard incapacitated, they debate on how to deal with him.
While elsewhere in the swamp, Edmond has followed the Man-Thing back into the swamp, figuring that if he can some how capture it he can make money off its captivity. He follows the bog-beast, as it and various lizards are drawn to the Lizard's mental commands for aid. When the lizards and Man-Thing arrive on the Connors property, Spider-Man mistakenly attacks the Man-Thing, while the lizards free the Lizard.
When Spider-Man realizes who the real enemy is, he attacks the Lizard and gets an assist from the Man-Thing. Meanwhile, when Edmond is informed as to Connor's identity, he has her take him to his lab, where he uses his scientific knowledge to come up with a cure for Connors. Getting into the middle of the battle, he almost drops the cure, but Spider-Man saves it from a spill with his webbing and uses it on the Lizard. The monster changes back into Curt Connors. Shortly after the lizards and the Man-Thing to the swamp. Edmond tells all present that until he met the Man-Thing he figured his life was over, but now has given things a second thought and is going to give life a second chance.
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