German submarine U-545 was a Type IXC U-boat of the Nazi German Kriegsmarine during World War II. She was laid down at the Deutsche Werft (yard) in Hamburg as 'werk' 366 on 1 August 1942, launched on 3 March 1943 and commissioned on 19 May with Kapitänleutnant Gert Mannesmann in command. U-545 began her service career with training as part of the 4th U-boat Flotilla from 19 May 1943. She was re-assigned to the 2nd flotilla for operations on 1 December. She carried out one patrol and damaged one ship. She was a member of five wolfpacks.
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