In the APG III system, adopted here, Hesperocallis is placed in the family Asparagaceae, subfamily Agavoideae, since recent molecular systematic studies ((Pires et al. 2004) have confirmed a close relationship with Agave. Other classifications have included the species in its own family, Hemerocallidaceae, or placed it in the Hostaceae (Funkiaceae); both families are submerged into the Agavoideae in the APG III system. As with many of the 'lilioid monocots', prior to the use of molecular evidence in classification, it was placed in the Liliaceae.
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