The Joker was one of several super villain inmates incarcerated in Gotham's infamous Arkham Asylum who was exposed to mutagen as part of a plot by the Shredder and Ra's al Ghul to take control of the city with a mutant army. The Joker was mutated into a cobra, increasing his strength and speed. Due to his proclivity for deadly poisons the aspect of his mutation that excited the Joker the most was a set of fangs with a potentially deadly venom.
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