About: Robotnikinin   Sponge Permalink

An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

"Robotnikinin", a macrocycle, was discovered when a Harvard University team used a small-molecule microarray to screen for molecules that bind to Sonic hedgehog, the most prominent protein in the pathway.

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  • Robotnikinin
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  • "Robotnikinin", a macrocycle, was discovered when a Harvard University team used a small-molecule microarray to screen for molecules that bind to Sonic hedgehog, the most prominent protein in the pathway.
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dbkwik:sonic/prope...iPageUsesTemplate
abstract
  • "Robotnikinin", a macrocycle, was discovered when a Harvard University team used a small-molecule microarray to screen for molecules that bind to Sonic hedgehog, the most prominent protein in the pathway. The Harvard team, led by Dr. Stuart Schreiber, decided to look for modulators that act before smoothened in the hedgehog pathway. Using the small-molecule microarray, they found a new macrocycle that bound directly to the Sonic hedgehog protein. They tested it on human skin cells and a synthetic skin model and found that robotnikinin inhibits Sonic hedgehog signaling in a concentration-dependent manner.”
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