Growing up in New York's Little Italy neighborhood, DeFeo joined the Luciano crime family under boss Frank Costello. When DeFeo became a made man, he entered a crew belonging to mobster Michele Miranda that operated in Lower Manhattan and Brooklyn. DeFeo soon aligned himself with capo Vito Genovese, who would depose Costello as boss in the late 1950s. When Genovese went to prison in 1959, DeFeo served under acting boss Thomas Eboli.
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