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An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

Estradiol (E2 or 17β-estradiol, also oestradiol) is a sex hormone. Estradiol is abbreviated E2 as it has 2 hydroxyl groups in its molecular structure. Estrone has 1 (E1) and estriol has 3 (E3). Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of estrone during the reproductive years of the human female. Thus it is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Estradiol i

AttributesValues
rdfs:label
  • Estradiol
rdfs:comment
  • Estradiol (E2 or 17β-estradiol, also oestradiol) is a sex hormone. Estradiol is abbreviated E2 as it has 2 hydroxyl groups in its molecular structure. Estrone has 1 (E1) and estriol has 3 (E3). Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of estrone during the reproductive years of the human female. Thus it is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Estradiol i
sameAs
IUPHAR ligand
  • 1012(xsd:integer)
dcterms:subject
dbkwik:babyish/pro...iPageUsesTemplate
ChEMBL
  • 135(xsd:integer)
CAS supplemental
  • 35380(xsd:integer)
bioavailability
  • 97(xsd:integer)
verifiedrevid
  • 488623959(xsd:integer)
metabolism
excretion
  • Urine, and sweat glands
StdInChIKey
  • VOXZDWNPVJITMN-ZBRFXRBCSA-N
ATC prefix
  • G03
Legal Status
  • S4 , POM , ℞-only
Width
  • 200(xsd:integer)
molecular weight
  • 272(xsd:double)
IUPAC name
  • -estra-1,3,5-triene-3,17-diol
PubChem
  • 5757(xsd:integer)
CAS number
  • 50(xsd:integer)
H
  • 24(xsd:integer)
InChI
  • 1(xsd:integer)
pregnancy category
  • X
smiles
  • C[C@]12CC[C@@H]3c4cccO
ChemSpiderID
  • 5554(xsd:integer)
ATC suffix
  • CA03
tradename
  • Climara, Menostar
elimination half-life
  • 46800.0
Image
  • Oestradiol-3D-balls.png
UNII
  • 4(xsd:integer)
synonyms
  • (-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol)
DrugBank
  • DB00783
StdInChI
  • 1(xsd:integer)
KEGG
  • D00105
ChEBI
  • 16469(xsd:integer)
routes of administration
  • Oral, transdermal
O
  • 2(xsd:integer)
C
  • 18(xsd:integer)
abstract
  • Estradiol (E2 or 17β-estradiol, also oestradiol) is a sex hormone. Estradiol is abbreviated E2 as it has 2 hydroxyl groups in its molecular structure. Estrone has 1 (E1) and estriol has 3 (E3). Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of estrone during the reproductive years of the human female. Thus it is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Estradiol is also present in males, being produced as an active metabolic product of testosterone. The serum levels of estradiol in males (14 - 55 pg/mL) are roughly comparable to those of postmenopausal women (< 35 pg/mL). Estradiol in vivo is interconvertible with estrone; estradiol to estrone conversion being favored. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones.
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