William Holmes Crosby Jr. was born in Wheeling, West Virginia. Six months later the family moved to Oil City, Pennsylvania. His father was an architect. His mother, Frances Irene Forrester, was a schoolteacher. Crosby was drawn toward medicine at an early age, attaching himself at age 12 to volunteer physicians who worked at the Boy scout camp he attended. In high school he discovered his love of literature from his sophomore English teacher, Dorothy Mann. Crosby attended University of Pennsylvania under a scholarship awarded to him by the Pennsylvania legislature. During this time, he began his life in research as a volunteer in the local hospital hematology lab.
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