About: Sidechain Position   Sponge Permalink

An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

It’s easy to ignore Sidechains in Foldit; you can get decent scores without ever looking at them and just playing with the Backbone's shape. But sidechains are what make each protein fold the way it does. The backbone is chemically identical in all proteins and serves only as scaffolding. It's the sidechains' interactions with their watery environment that causes the protein to bend and fold up the way it does.

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  • Sidechain Position
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  • It’s easy to ignore Sidechains in Foldit; you can get decent scores without ever looking at them and just playing with the Backbone's shape. But sidechains are what make each protein fold the way it does. The backbone is chemically identical in all proteins and serves only as scaffolding. It's the sidechains' interactions with their watery environment that causes the protein to bend and fold up the way it does.
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abstract
  • It’s easy to ignore Sidechains in Foldit; you can get decent scores without ever looking at them and just playing with the Backbone's shape. But sidechains are what make each protein fold the way it does. The backbone is chemically identical in all proteins and serves only as scaffolding. It's the sidechains' interactions with their watery environment that causes the protein to bend and fold up the way it does. So, even though we tend to focus on the shape of the backbone in Foldit, moving it around and rebuilding and so on, it’s good to remember that it’s the sidechains we’re trying to make happy - we want to minimize sidechains clashing with each other, and minimize stress in the backbone angles caused by sidechain quibbles. Foldit gives us some great Tools to do this. You just need a little Strategy to get the best possible scores.
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