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An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

Diphenhydramine hydrochloride (/[unsupported input]ˌdaɪfɛnˈhaɪdrəmiːn/; abbreviated DPH, sometimes DHM) is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties which is mainly used to treat allergies. Like most other first-generation antihistamines, the drug also has a powerful hypnotic effect, and for this reason is often used as a non-prescription sleep aid. It is produced and marketed under the trade name Benadryl by McNeil-PPC (a division of Johnson & Johnson) in the U.S., Canada and South Africa (other trade names in other countries: Dimedrol, Daedalon). It is also available as a generic or store brand medication. It is also found in the name-brand products Nytol, Unisom, Tylenol PM, Excedrin PM, Midol PM and Advil PM, though so

AttributesValues
rdfs:label
  • Diphenhydramine
rdfs:comment
  • Diphenhydramine hydrochloride (/[unsupported input]ˌdaɪfɛnˈhaɪdrəmiːn/; abbreviated DPH, sometimes DHM) is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties which is mainly used to treat allergies. Like most other first-generation antihistamines, the drug also has a powerful hypnotic effect, and for this reason is often used as a non-prescription sleep aid. It is produced and marketed under the trade name Benadryl by McNeil-PPC (a division of Johnson & Johnson) in the U.S., Canada and South Africa (other trade names in other countries: Dimedrol, Daedalon). It is also available as a generic or store brand medication. It is also found in the name-brand products Nytol, Unisom, Tylenol PM, Excedrin PM, Midol PM and Advil PM, though so
sameAs
IUPHAR ligand
  • 1224(xsd:integer)
dcterms:subject
dbkwik:babyish/pro...iPageUsesTemplate
dbkwik:house/prope...iPageUsesTemplate
ChEMBL
  • 1620(xsd:integer)
bioavailability
  • 40(xsd:integer)
verifiedrevid
  • 460791686(xsd:integer)
metabolism
  • Various cytochrome P450 liver enzymes: CYP2D6 , 3A4
excretion
  • 94(xsd:integer)
StdInChIKey
  • ZZVUWRFHKOJYTH-UHFFFAOYSA-N
ATC prefix
  • D04
Legal Status
  • Over-the-counter
N
  • 1(xsd:integer)
molecular weight
  • 255(xsd:double)
protein bound
  • 98(xsd:integer)
IUPAC name
  • 2(xsd:integer)
PubChem
  • 3100(xsd:integer)
CAS number
  • 58(xsd:integer)
H
  • 21(xsd:integer)
InChI
  • 1(xsd:integer)
pregnancy AU
  • A
MedlinePlus
  • a682539
Verifiedfields
  • changed
smiles
  • OCc2ccccc2
ChemSpiderID
  • 2989(xsd:integer)
ATC suffix
  • AA32
tradename
  • Benadryl, Unisom, Sominex
pregnancy US
  • B
elimination half-life
  • 9000.0
  • 6480.0
  • 15120.0
UNII
  • 8(xsd:integer)
ATC supplemental
  • ,
Watchedfields
  • changed
DrugBank
  • DB01075
StdInChI
  • 1(xsd:integer)
KEGG
  • D00669
ChEBI
  • 4636(xsd:integer)
routes of administration
  • Oral, parenteral (IM), parenteral (IV), topical, suppository
O
  • 1(xsd:integer)
C
  • 17(xsd:integer)
abstract
  • Diphenhydramine hydrochloride (/[unsupported input]ˌdaɪfɛnˈhaɪdrəmiːn/; abbreviated DPH, sometimes DHM) is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties which is mainly used to treat allergies. Like most other first-generation antihistamines, the drug also has a powerful hypnotic effect, and for this reason is often used as a non-prescription sleep aid. It is produced and marketed under the trade name Benadryl by McNeil-PPC (a division of Johnson & Johnson) in the U.S., Canada and South Africa (other trade names in other countries: Dimedrol, Daedalon). It is also available as a generic or store brand medication. It is also found in the name-brand products Nytol, Unisom, Tylenol PM, Excedrin PM, Midol PM and Advil PM, though some Unisom products contain doxylamine instead. It is available as an over-the-counter (OTC) or prescribed HCl injectable. It may also be used for the treatment of extrapyramidal side-effects of many antipsychotics, such as the tremors that haloperidol can cause. In addition, injectable diphenhydramine can be used for life-threatening reactions (anaphylaxis) to allergens such as bee stings, peanuts, or latex, rather than risking the side-effects of epinephrine. It is a member of the ethanolamine class of antihistaminergic agents. Diphenhydramine was one of the first known antihistamines, invented in 1943 by Dr. George Rieveschl, a former professor at the University of Cincinnati. In 1946, it became the first prescription antihistamine approved by the U.S. Food and Drug Administration (FDA).
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