Lucas Lorenzo "Luke" Spencer Sr. is a fictional character on the popular ABC soap opera, General Hospital. He is the middle child of the late, Tim Spencer and his late wife, Lena Spencer. He was portrayed by Anthony Geary from November 20, 1978 to July 27, 2015, when Geary decided to retire. Luke often calls people who he is close to by their real names. He calls his niece, Carly, Caroline; his sister, Bobbie, Barbara Jean; his daughter, Lulu, Lesley Lu; and his good friend, Alexis, Natasha.