| rdfs:comment
| - Creatinine is a natural by-product of the break down of muscle tissue in the body. It is created on a more or less constant basis by all persons, the rate depending directly on the amount of muscle mass they have. It is filtered out of the body by the kidneys with a small amount passing into urine but the majority being used to create other molecules by normal bodily processes.
- Creatinine (from the Greek kreas, flesh) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Chemically, creatinine is a spontaneously formed cyclic derivative of creatine. Creatinine is chiefly filtered out of the blood by the kidneys, though a small amount is actively secreted by the kidneys into the urine. There is little-to-no tubular reabsorption of creatinine. If the filtering of the kidney is deficient, blood levels rise. Therefore, creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR). The GFR is clinically important because it is a measurement of renal function. However, in cases of severe renal
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| abstract
| - Creatinine (from the Greek kreas, flesh) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Chemically, creatinine is a spontaneously formed cyclic derivative of creatine. Creatinine is chiefly filtered out of the blood by the kidneys, though a small amount is actively secreted by the kidneys into the urine. There is little-to-no tubular reabsorption of creatinine. If the filtering of the kidney is deficient, blood levels rise. Therefore, creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR). The GFR is clinically important because it is a measurement of renal function. However, in cases of severe renal dysfunction, the creatinine clearance rate will be "overestimated" because the active secretion of creatinine will account for a larger fraction of the total creatinine cleared. Ketoacids, cimetidine and trimethoprim reduce creatinine tubular secretion and therefore increase the accuracy of the GFR estimate, particularly in severe renal dysfunction. (In the absence of secretion, creatinine behaves like inulin.) A more complete estimation of renal function can be made when interpreting the blood (plasma) concentration of creatinine along with that of urea. BUN-to-creatinine ratio (the ratio of urea to creatinine) can indicate other problems besides those intrinsic to the kidney; for example, a urea level raised out of proportion to the creatinine may indicate a pre-renal problem such as dehydration. Men tend to have higher levels of creatinine because they generally have more skeletal muscle than women. Vegetarians have been shown to have lower creatinine levels.
- Creatinine is a natural by-product of the break down of muscle tissue in the body. It is created on a more or less constant basis by all persons, the rate depending directly on the amount of muscle mass they have. It is filtered out of the body by the kidneys with a small amount passing into urine but the majority being used to create other molecules by normal bodily processes. Since the rate of creation and filtering of creatinine is generally constant, a high level of creatinine in the blood is generally a good indicator of kidney function, with high levels indicating kidney dysfunction or failure. However, as an individual's "natural" creatinine level might vary from person to person, monitoring the trend of the creatinine level is a better diagnostic indicator than the absolute creatinine level.
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