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| - O'Brien era un marine a bordo della Reach Station Gamma, durante la Caduta di Reach.
- O'Brien is the main antagonist in George Orwell's dystopian novel Nineteen Eighty-Four. He's a member of INGSOC's Inner Party. The protagonist Winston Smith, feels strangely drawn to him. Orwell never reveals O'Brien's first name.
- He received SG-1's IDC after they were trapped on P2X-887. (SG1: "Zero Hour")
- Agent O'Brien was a member of the Department of Floaters, partnered with Agent Van Dyne and later with Chliever the Corroder. O'Brien, with Van Dyne, recruited Chliever from a Suefic in which Van Dyne was killed. It is known that O'Brien was already a senior agent by this point. After Van Dyne's aforementioned death, Chliever became O'Brien's partner and the two became good friends. The pair avoided the Macrovirus emergency entirely, but during the 2008 Mary Sue Invasion, O'Brien was slain by a Villain!Sue impersonating Mai from Avatar: The Last Airbender.
- O'Brien is a S.H.I.E.L.D. agent who worked with Phil Coulson and Melinda May during a mission to capture an Inhuman, during which O'Brien and his team were briefly brainwashed. After the capture of Robert Gonzales' S.H.I.E.L.D. base, he was sent to monitor the agent Fitz who expressed a desire to leave S.H.I.E.L.D.. Later he assisted in the attempted killing of Hive. However O'Brien was later caught in a trap and transformed into one of the Primitives with a bomb containing the Absolution Virus.
- O'Brien are a company active in the UK. They are currently building private terraced homes in the Johnstone Castle estate in Johnstone, near Glasgow. Among other projects, they were responsible for numerous housing estates built in Houston in the 1990s.
- O'Brien is the supervisor at the District Attorney's office in Los Angeles, California.
- O'Brien was a S.H.I.E.L.D. agent who worked with Phil Coulson and Melinda May in Bahrain.
- O'Brien är en manlig Tau'ri och är en Sergeant i USA:s Flygvapen stationerad i Stargate Command. Hans inlägg är som en tekniker i Stargate Operation rummet, som ansvarar för verksamheten där.
- O'Brien served Bruno Borgia and his gang. He was also responsible for bringing Bruno's pregnant wife Isabella Borgia to a nearby museum. On the night when Isabella went into labor, O'Brien met with his boss and explained that he helped bring Isabella to the museum and set her up inside safe and guarded.
- When Porker Lewis accidentally arrived in the Special Zone through a Portal Ring, it didn't take long for the police to recognise Porker as wanted criminal "Oscar the Pig". O'Brien's team of officers (minus O'Brien himself) and Furor tracked Porker down to The Purple Mushroom bar and arrested him. However, at the station, Porker revealed the true nature of his history with Hammerhead, causing Furor to sympathise with the pig. Furor called O'Brien into the room and angrily asked why he had arrested someone that looked nothing like Oscar. O'Brien began to argue that Porker did look like Oscar, but Furor's mention of a promotion slipping away caused him to backpedal. O'Brien offered to continue searching for Oscar, but Furor insisted Oscar would never be seen in the Special Zone again.
- O'Brien could refer to:
* Miles O'Brien, transporter chief aboard the USS Enterprise-D, and Chief of Operations aboard Deep Space 9
* Miles O'Brien (mirror), the mirror universe version, also known as "Smiley"
* Miles O'Brien (replicant), a replicant created by the Parada government
* Keiko O'Brien, biologist and wife to Miles O'Brien
* Molly O'Brien, first child of Miles and Keiko O'Brien
* Kirayoshi O'Brien, second child of Miles and Keiko O'Brien
* Michael O'Brien, father of Miles O'Brien
* Miranda O'Brien, an alternate timeline descendant of Miles O'Brien
* Sean Aloysius O'Brien, labor union leader in the 20th century, and ancestor to Miles O'Brien
* O'Brien family, the family unit that Miles and Keiko belong to
* O'Brien, a character in the
- O'Brien was a United States Navy captain. Multiply decorated in the Persian Gulf, Europe, and Africa, he was praised in the mass media as a competent and noble-minded military man who was well-liked by his fellow soldiers.
- Bei einer Attentatsmission musste O'Brien zusammen mit Dutch, Cal-141 und zwei weiteren ODSTs einen San 'Shyuum töten um so die Versorgungswege der Allianz zu stoppen. Bei dieser Mission rettete Cal-141 O'Brien dreimal das Leben. Beim ersten Mal warf sie O'Briens HEV aus einem Teich, beim zweiten mal hielt sie einen Jiralhanae vom Schlag mit seinem Typ-2 Gravitationshammer ab und beim dritten mal stieß sie O'Brien weg und bekam deshalb einen weiteren Schlag des Brutes gegen den Kopf. Da sie durch den Schlag tödlich verwundet wurde, befahl sie O'Brien den Schuss zu übernehmen. Vorher konnten die drei ODST, den Jiralhanae zu Boden werfen und mit gezielten Schüssen auf seinen Kopf töten. O'Brien schaffte es schließlich den San 'Shyuum zu töten und sorgte so für den Erfolg des UNSC bei dieser
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