Diseases are scary. However germs are rather small. This leads to a bit of a problem. You see, scary things can make good villains, but you need to be able to see them. This has lead to writers coming up with two different but functionally similar solutions to this problem. Either have the microbe get really really big or have the hero get really really small. This runs almost entirely on You Fail Biology Forever and the most extreme form of Square-Cube Law. Examples of Mega Microbes include:
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