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O-1783 was a small-molecule chemical compound that was a dopamine reuptake inhibitor with an IC50 of 17 nM. It was a methylphenidate analogue of a aryltetrahydropyranyl methyl esther core chemical scaffold that was a potent transporter inhibitor that was nearly 35% biologically active than DL-threo methylphenidate.

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  • O-1783
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  • O-1783 was a small-molecule chemical compound that was a dopamine reuptake inhibitor with an IC50 of 17 nM. It was a methylphenidate analogue of a aryltetrahydropyranyl methyl esther core chemical scaffold that was a potent transporter inhibitor that was nearly 35% biologically active than DL-threo methylphenidate.
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abstract
  • O-1783 was a small-molecule chemical compound that was a dopamine reuptake inhibitor with an IC50 of 17 nM. It was a methylphenidate analogue of a aryltetrahydropyranyl methyl esther core chemical scaffold that was a potent transporter inhibitor that was nearly 35% biologically active than DL-threo methylphenidate.
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