About: Ultralente   Sponge Permalink

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Ultralente is not used very successfully in dogs, but has been widely used in treatment of cats. With an onset of 1-4 hours and a duration of 12-24 hours. Most cats require 2 ultralente shots a day. Ultralente absorption can be erratic, with about 20% not responding to the insulin--not even with twice-daily dosing. Most humans not using an analog intermediate or long acting insulin for basal needs are or were using either NPH or Lente on an average of twice a day.

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  • Ultralente
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  • Ultralente is not used very successfully in dogs, but has been widely used in treatment of cats. With an onset of 1-4 hours and a duration of 12-24 hours. Most cats require 2 ultralente shots a day. Ultralente absorption can be erratic, with about 20% not responding to the insulin--not even with twice-daily dosing. Most humans not using an analog intermediate or long acting insulin for basal needs are or were using either NPH or Lente on an average of twice a day.
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abstract
  • Ultralente is not used very successfully in dogs, but has been widely used in treatment of cats. With an onset of 1-4 hours and a duration of 12-24 hours. Most cats require 2 ultralente shots a day. Ultralente absorption can be erratic, with about 20% not responding to the insulin--not even with twice-daily dosing. Human ultralente insulin was not very reliable when used with many people, either. This is why it wasn't widely used enough to remain on either Eli Lilly's or Novo Nordisk's product list. There's great variability from patient to patient with this insulin. Conclusion in this abstract is it has far too much day-to-day variability to be truly useful for many. Some people absorb r-DNA ultralente at a faster than usual rate, so for them it would have only the duration of an insulin.. One injection of Bovine Ultralente insulin can last up to 40 hours when administered to a human--longer than Lantus; it is also peakless. The human duration with Bovine ultralente is due, in part, to the 3 amino acid differences between bovine and human insulin. Most humans not using an analog intermediate or long acting insulin for basal needs are or were using either NPH or Lente on an average of twice a day.
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