German submarine U-216 was a Type VIID mine-laying U-boat of the Nazi German Kriegsmarine during World War II. She was one of six U-boats of her kind, equipped with special vertical tubes that launched the mines. Her keel was laid down 1 January 1941 by Germaniawerft in Kiel as 'werk' 648. She was launched on 23 October 1941 and commissioned on 15 December 1941 with Oberleutnant Karl-Otto Schultz in command.