About: Binder puzzle

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About: Binder puzzle Sponge Permalink

An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

In many binder puzzles, the binder portion is mostly available for design. Some parts of the binder may be locked or held in place by constraints. Most of the segments in the binder are normally mutable. In some puzzles, the binding area is part of a larger protein, in which case much of the protein may be locked, with only certain segments mutable. The target in a binder puzzle is generally more or less fixed. Much of the target may be locked. It may be possible to wiggle the sidechains of part of the target, but generally the target's backbone has a fixed shape.

Attributes	Values
rdfs:label	Binder puzzle
rdfs:comment	In many binder puzzles, the binder portion is mostly available for design. Some parts of the binder may be locked or held in place by constraints. Most of the segments in the binder are normally mutable. In some puzzles, the binding area is part of a larger protein, in which case much of the protein may be locked, with only certain segments mutable. The target in a binder puzzle is generally more or less fixed. Much of the target may be locked. It may be possible to wiggle the sidechains of part of the target, but generally the target's backbone has a fixed shape.
dcterms:subject	Puzzle Types dbkwik:resource/SmmkF-eBKeTUOGVLPiS1Bw==
abstract	In many binder puzzles, the binder portion is mostly available for design. Some parts of the binder may be locked or held in place by constraints. Most of the segments in the binder are normally mutable. In some puzzles, the binding area is part of a larger protein, in which case much of the protein may be locked, with only certain segments mutable. The target in a binder puzzle is generally more or less fixed. Much of the target may be locked. It may be possible to wiggle the sidechains of part of the target, but generally the target's backbone has a fixed shape. The targets of binder puzzle designs have included the antibiotic vancomycin, the Ebola and Marburg viruses, and the Abeta (Aβ) polypeptide associated with the "plaques" found in Alzheimer's disease. A successful binder design could lead to new drug therapies. In the case of viruses, simply binding to the surface of the virus could prevent the virus from infecting healthy cells. For Alzheimer's disease, binding to the plaques would be a first step toward therapies to either eliminate the plaques or render them harmless. Here are some examples of binder puzzles with links to the puzzle page in Foldit and the uploaded images here on the wiki.

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