Luis de Santángel (unknown – 1498) was a baptized Jew born in Valencia and the finance minister of King Ferdinand II. He assisted the explorer Christopher Columbus in his negotiations with Queen Isabella I of Castile to acquire funding for his voyage across the Atlantic Ocean, ultimately financing most of it himself. As a member of the Spanish Brotherhood of Assassins, he aided Ezio Auditore da Firenze and Raphael Sánchez in foiling a Templar conspiracy in the Granada War. Late in his life, he turned against Queen Isabella and plotted to poison her when she became lost to Templar influence though this assassination was only completed after his death.
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