NPH was first launched in 1946 in Denmark by as the first longer-lasting neutral pH insulin for human use. "Hagedorn", was the chief scientist who invented it. The difference between NPH/isophane insulin and PZI insulin is the amount of protamine in the suspension. PZI has more of it and this is what makes it a slow-acting insulin, in contrast to NPH/isophane being an intermediate-acting (or in some cats, short-acting) one, as the additional protamine extends the duration.
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