Man-Spider is the mutated form of Spider-Man which appears in both the comics and in the 1990s animated series.
When Spider-Man's body began to mutate further he sought out the help of Dr. Mariah Crawford who gave him what she believed to be a cure. However, it accelerated the changes and he grew four extra arms, for a total of eight limbs, six arms and two legs. Peter still felt he needed to capture Michael Morbius, and then the Punisher arrived to kill Spider-Man, believing the media. Spider-Man eventually mutated further into a creature dubbed "Man Spider". Somehow, Vulture seemed to cure himself of the Man Spider mutation but then faced problems where he constantly changed his age.