The Gray Death occurs when an individual without a predisposition for nanoaugmentation is infected with nanites. The nanites integrate themselves into the individual's cells and the individual's body rejects the nanites, and by extension the cells that the nanites have integrated with. The virus can be halted by the use of Ambrosia, a vaccine that consists of ROM modules which attach to the nanites. The virus and vaccine both must be manufactured in a Universal Constructor.
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