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| - Warfarin är ett blodförtunnande medel från Jorden. Senator Alan Armstrong tog Warfarin för hans hjärta, men efter att han evakuerades ombord på Destiny med resten av Tau'ri under 2009 man upptäckte att han hade en stor blåmärke och inre blödningar, som warfarin kan göra värre. (SGU: "Air, Part 2")
- Warfarin is the most commonly prescribed blood thinner and is used to prevent clotting and resulting embolisms. Ironically, it was first developed as a rodent poison (causing massive internal bleeding when it is ingested), but since the 1950s has been used as a pharmaceutical (ironically, after someone attempting to consume rat poison in a suicide attempt survived it). It was first developed after animals died of internal bleeding after consuming mouldy hay, but the active ingredient was not identified until several years later. Warfarin works by preventing chemical reduction of Vitamin K
- Warfarin (also known under the brand names Coumadin, Jantoven, Marevan, Lawarin, Waran, and Warfant) is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. It was initially introduced in 1948 as a pesticide against rats and mice and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s warfarin was found to be effective and relatively safe for preventing thrombosis and embolism (abnormal formation and migration of blood clots) in many disorders. It was approved for use as a medication in 1954 and has remained popular ever since; warfarin is the most widely prescribed oral anticoagul
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| abstract
| - Warfarin (also known under the brand names Coumadin, Jantoven, Marevan, Lawarin, Waran, and Warfant) is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. It was initially introduced in 1948 as a pesticide against rats and mice and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s warfarin was found to be effective and relatively safe for preventing thrombosis and embolism (abnormal formation and migration of blood clots) in many disorders. It was approved for use as a medication in 1954 and has remained popular ever since; warfarin is the most widely prescribed oral anticoagulant drug in North America. Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods (particularly leaf vegetable foods or "greens," since these typically contain large amounts of vitamin K1) and its activity has to be monitored by blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken. A high INR predisposes to a high risk of bleeding, while an INR below the therapeutic target indicates that the dose of warfarin is insufficient to protect against thromboembolic events. Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K1 to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. Despite being labeled a vitamin K antagonist,[2] warfarin does not antagonize the action of vitamin K1, but rather antagonizes vitamin K1 recycling, depleting active vitamin K1. Thus, the pharmacologic action may always be reversed by fresh vitamin K1. When administered, these drugs do not anticoagulate blood immediately. Instead, onset of their effect requires about a day before remaining active clotting factors have had time to naturally disappear in metabolism, and the duration of action of a single dose of warfarin is 2 to 5 days. Reversal of warfarin's effect when it is discontinued or vitamin K1 is administered, requires a similar time. Warfarin is a synthetic derivative of dicoumarol, a 4-hydroxycoumarin-derived mycotoxin anticoagulant originally discovered in spoiled sweet clover-based animal feeds. Dicoumarol, in turn, is derived from coumarin, a sweet-smelling but coagulation-inactive chemical found naturally in "sweet" clover (to which it gives its odor and name), tonka beans (also known as "cumaru" from which coumarin's name derives) and many other plants. The name warfarin stems from its discovery at the University of Wisconsin, incorporating the acronym for the organization which funded the key research (WARF, for Wisconsin Alumni Research Foundation) and the ending -arin, indicating its link with coumarin.
- Warfarin är ett blodförtunnande medel från Jorden. Senator Alan Armstrong tog Warfarin för hans hjärta, men efter att han evakuerades ombord på Destiny med resten av Tau'ri under 2009 man upptäckte att han hade en stor blåmärke och inre blödningar, som warfarin kan göra värre. (SGU: "Air, Part 2")
- Warfarin is the most commonly prescribed blood thinner and is used to prevent clotting and resulting embolisms. Ironically, it was first developed as a rodent poison (causing massive internal bleeding when it is ingested), but since the 1950s has been used as a pharmaceutical (ironically, after someone attempting to consume rat poison in a suicide attempt survived it). It was first developed after animals died of internal bleeding after consuming mouldy hay, but the active ingredient was not identified until several years later. Warfarin is slower acting than heparin, but can be given orally (heparin must be injected) and last longer in the body leading to longer periods of time between doses. Despite its effectiveness and widespread use, it does require precautions. It interacts with many other drugs and even some foods. For example, it interacts with many common antibiotics and alcohol. Foods high in Vitamin K (such as leafy vegetables) also inhibit its action. The patient's international normalized ratio must be constantly monitored to ensure the patient is receiving an appropriate dose. It is contra-indicated for use during pregnancy as it can cause abnormalities in the fetus in the first three months of development. Warfarin works by preventing chemical reduction of Vitamin K See also Warfarin induced necrosis
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