About: Bicuculline   Sponge Permalink

An Entity of Type : dbkwik:resource/rq8Z6H1D5ZQ6xf9ogWx0pw==, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

Its blockade of GABAAR activity leads to significant promotion of embryonic stem (ES) and neural stem (NSC) cell proliferation and cell-cycle progression. Its in vivo clinical administration to humans is contraindicated because it significantly increases the occurrence on non-familial cases of juvenile myoclonic epilepsy and childhood absence epilepsy because of its blockade of endogenous GABAergic inhibitory central nervous signaling and it is believed to significantly increase the occurrence of central nervous cancer by its promotion of neural stem cell and neural progenitor cell (NPC) self-renewal.

AttributesValues
rdf:type
rdfs:label
  • Bicuculline
rdfs:comment
  • Its blockade of GABAAR activity leads to significant promotion of embryonic stem (ES) and neural stem (NSC) cell proliferation and cell-cycle progression. Its in vivo clinical administration to humans is contraindicated because it significantly increases the occurrence on non-familial cases of juvenile myoclonic epilepsy and childhood absence epilepsy because of its blockade of endogenous GABAergic inhibitory central nervous signaling and it is believed to significantly increase the occurrence of central nervous cancer by its promotion of neural stem cell and neural progenitor cell (NPC) self-renewal.
sameAs
side
  • *Significantly increased occurrence of non-familial epilepsy *Significantly increased occurrence of central nervous cancer
dbkwik:halo-fanon/...iPageUsesTemplate
dbkwik:halofanon/p...iPageUsesTemplate
Molweight
  • 367(xsd:double)
Name
  • Bicuculline
Chemformula
  • C20H17NO6
Mechanism
  • GABAAR inhibitor
hidepharma
  • yes
Clinuse
  • Promotion of neural stem cell self-renewal
IUPAC name
  • -6(xsd:integer)
Route
  • Oral
abstract
  • Its blockade of GABAAR activity leads to significant promotion of embryonic stem (ES) and neural stem (NSC) cell proliferation and cell-cycle progression. Its in vivo clinical administration to humans is contraindicated because it significantly increases the occurrence on non-familial cases of juvenile myoclonic epilepsy and childhood absence epilepsy because of its blockade of endogenous GABAergic inhibitory central nervous signaling and it is believed to significantly increase the occurrence of central nervous cancer by its promotion of neural stem cell and neural progenitor cell (NPC) self-renewal.
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