About: Calbindin   Sponge Permalink

An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

The transport of calcium across the enterocyte cytoplasm appears to be rate-limiting for calcium absorption in the intestine; the presence of calbindin increases the amount of calcium crossing the cell without raising the free concentration. Calbindin-D9k may also stimulate the basolateral calcium-pumping ATPases. Expression of calbindin-D9k and calbindin-D28k are both stimulated by the active vitamin D metabolite, calcitriol although the precise mechanisms are still controversial. In mice in which the receptor for vitamin D is not expressed, calbindin-D9k is reduced, but not absent.

AttributesValues
rdfs:label
  • Calbindin
rdfs:comment
  • The transport of calcium across the enterocyte cytoplasm appears to be rate-limiting for calcium absorption in the intestine; the presence of calbindin increases the amount of calcium crossing the cell without raising the free concentration. Calbindin-D9k may also stimulate the basolateral calcium-pumping ATPases. Expression of calbindin-D9k and calbindin-D28k are both stimulated by the active vitamin D metabolite, calcitriol although the precise mechanisms are still controversial. In mice in which the receptor for vitamin D is not expressed, calbindin-D9k is reduced, but not absent.
sameAs
dcterms:subject
dbkwik:babyish/pro...iPageUsesTemplate
Name
  • calbindin 1, 28kDa
  • calbindin 2, 29kDa
OMIM
  • 114050(xsd:integer)
  • 114051(xsd:integer)
Caption
  • NMR solution structure of Ca2+-loaded calbindin D28K.
EntrezGene
  • 793(xsd:integer)
  • 794(xsd:integer)
UniProt
  • P05937
  • P22676
ARM
  • p
  • q
Title
  • The Ramachandran plot on PDB
HGNCid
  • 1434(xsd:integer)
  • 1435(xsd:integer)
RefSeq
  • NM_001740
  • NM_004929
Symbol
  • CALB1
  • CALB2
Chromosome
  • 8(xsd:integer)
  • 16(xsd:integer)
url
Band
  • 11(xsd:integer)
  • 22(xsd:double)
AltSymbols
  • CALB
abstract
  • The transport of calcium across the enterocyte cytoplasm appears to be rate-limiting for calcium absorption in the intestine; the presence of calbindin increases the amount of calcium crossing the cell without raising the free concentration. Calbindin-D9k may also stimulate the basolateral calcium-pumping ATPases. Expression of calbindin-D9k and calbindin-D28k are both stimulated by the active vitamin D metabolite, calcitriol although the precise mechanisms are still controversial. In mice in which the receptor for vitamin D is not expressed, calbindin-D9k is reduced, but not absent.
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