The 12th Arkansas Infantry (1861–1865) was a Confederate Army infantry regiment during the American Civil War. The regiment spent much of its service defending Confederate strong points along the Mississippi River. The unit participated in the defense of Island No. 10 in early 1862 and later became part of the garrison of Port Hudson in 1863. Following the capitulation of the garrison of Port Hudson, the survivors of the 12th were eventually paroled and exchanged back to Arkansas where the regiment was consolidated with the remants of several other Arkansas regiments to become the 2nd Arkansas Consolidated Infantry Regiment.