After the Searing you can find Gwen's Broken Flute in Ascalon as a remnant of Gwen (a Tattered Girl's Cape also used to be found in Kryta, but no longer appears). In Elona, players adventuring in Barbarous Shore will find a Preserved Red Iris Flower in an unlocked chest. All these items are marked as Quest Items. All these item can be used in Eye of the North to start the quest Fire and Pain. If you have a Prophecies Character and have a Tapestry Shred in your inventory then Gwen will offer you the quest Then and Now, Here and There. (you must complete the quest The Missing Vanguard first)