The Local wiggle tool is related to the regular wiggle, but works differently. As with many things in Foldit, the technical details of the differences between wiggle and local wiggle are not publicly known. All that's really known is how to select and use the two tools. Local wiggle is most commonly used during endgame. Local wiggle can often find small gains when other tools can't. Early on, sirenbrian and other Foldit players developed Local Wiggle Strategy, which involved using local wiggle on small sections of protein. Many endgame "LWS" recipes use variations on this strategy.