M.U.T.H.E.R is an old super computer with a female AI created by Jonas Venture Sr. to help run The Venture Compound and act as the overseer of an underground nuclear fallout zone and make them fully automated. Her main duty also consisted of releasing small amounts of mood altering gas into the fallout zone to ensure the happiness of its future inhabitants. However, she eventually became corrupt, causing her to act irrational, possessive and make dangerously violent decisions.