He was educated at the University of La Sapienza, gaining degrees utroque iure, in both canon and civil law. He was ordained October 23, 1740. He was appointed titular Archbishop of Petra, December 23, 1766, and cardinal priest in the consistory of April 19, 1773. Appointed by means of a papal brief of Pope Clement XIV, he was the principal negotiator for the Holy See and composer of the brief Dominus ac Redemptor of June 8, 1773, that suppressed the Society of Jesus. On 2 October, the Diario di Roma reported he had been given a Meissen group representing the death of St. Francis Xavier, confiscated from the Jesuits.