George I Ghisi () was a Latin feudal lord in medieval Greece. A son of Bartholomew I Ghisi, through his first marriage to a daughter of Guy II of Dramelay he was Baron of Chalandritsa in the Principality of Achaea, and is named also as castellan of Kalamata in 1292. In 1303, when his father died, he inherited the lordship of the Aegean islands of Tinos, Mykonos, with fiefs on Serifos and Keos. Through his second wife, Alice dalle Carceri, he also became baron ("triarch") of Negroponte (Euboea). He was killed in the Battle of the Cephissus against the Catalan Company in 1311. His wife Alice died in 1313.