In 2267, the ship was assigned to monitor covert activity in the Reach related to organized crime. It was damaged later that year when Vanguard came under attack by the Shedai Wanderer. (VAN novel: Precipice) In 2268, along with the USS Akhiel and the USS Theseus, the Buenos Aires which had been assigned to Vanguard on a interim basis had been reassigned by Starfleet Command to missions of equal or greater importance. (VAN novel: What Judgments Come) In the 2280s, the Buenos Aires was outfitted for duty as a heavy cruiser (NCA). (TOS video game: Starfleet Command)